Phenotypes associated with this allele

• Allele Symbol: Ftx^tm1.2Ics
• Allele Name: targeted mutation 1.2, Mouse Clinical Institute
• Allele ID: MGI:8280706
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ftx^tm1.2Ics/Ftx^tm1.2Ics	Not Specified	MGI:8280959

Genotype
MGI:8280959

hm1

• Allelic Composition: Ftx^tm1.2Ics/Ftx^tm1.2Ics
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

enlarged spleen ( J:378077 )

♀ • at ages 1 and 2 years

♀ • normal size spleen at age 3 months

hematopoietic system

enlarged spleen ( J:378077 )

♀ • at ages 1 and 2 years

♀ • normal size spleen at age 3 months

increased myeloid dendritic cell number ( J:378077 )

♀ • in spleen

increased plasmacytoid dendritic cell number ( J:378077 )

♀

increased B cell number ( J:378077 )

♀ • increased spontaneously activated CD69+ cells in spleen

♀ • increased age-associated B cell frequency at age 1 year

increased germinal center B cell number ( J:378077 )

♀ • increased frequency at age 1 year

increased activated T cell number ( J:378077 )

♀ • increased spontaneously activated CD69+ cells in spleen

increased macrophage cell number ( J:378077 )

♀

increased myeloid cell number ( J:378077 )

♀ • in spleen

increased IgG level ( J:378077 )

♀ • total level in serum

♀ • higher levels of anti-RNP-Sm, anti-RNA and ant-DNA IgG in serum at ages, 3 months, 1 year and 1.5+ years

increased IgG2b level ( J:378077 )

♀ • in serum

increased IgG2c level ( J:378077 )

♀ • in serum

increased IgM level ( J:378077 )

♀ • in serum

immune system

immune system phenotype ( J:378077 , J:378077 )

♀N • normal cell organization and no fibrosis or cell infiltration in spleen (J:378077)

♀N • normal serum cytokine levels at ages 3 months and 1 year (J:378077)

♂N • normal spleen (J:378077)

enlarged spleen ( J:378077 )

♀ • at ages 1 and 2 years

♀ • normal size spleen at age 3 months

increased myeloid dendritic cell number ( J:378077 )

♀ • in spleen

increased plasmacytoid dendritic cell number ( J:378077 )

♀

increased B cell number ( J:378077 )

♀ • increased spontaneously activated CD69+ cells in spleen

♀ • increased age-associated B cell frequency at age 1 year

increased germinal center B cell number ( J:378077 )

♀ • increased frequency at age 1 year

increased activated T cell number ( J:378077 )

♀ • increased spontaneously activated CD69+ cells in spleen

increased macrophage cell number ( J:378077 )

♀

increased IgG level ( J:378077 )

♀ • total level in serum

♀ • higher levels of anti-RNP-Sm, anti-RNA and ant-DNA IgG in serum at ages, 3 months, 1 year and 1.5+ years

increased IgG2b level ( J:378077 )

♀ • in serum

increased IgG2c level ( J:378077 )

♀ • in serum

increased IgM level ( J:378077 )

♀ • in serum