Gpr15lg^em1Darl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gpr15lg^em1Darl
• Name: G protein coupled receptor 15 ligand; endonuclease-mediated mutation 1, Dan R Littman
• MGI ID: MGI:8276514
• Synonyms: C10orf99ⁿ
• Gene: Gpr15lg Location: Chr14:36824097-36832058 bp, - strand Genetic Position: Chr14, 21.29 cM
• Alliance: Gpr15lg^em1Darl page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• CRISPR/cas9-mediated recombination inserted a premature stop codon in exon 1. (J:371435)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpr15lg Mutation: 7 strains or lines available

References

• Original: J:371435 O'Connor GJ, et al., C10ORF99 (GPR15L) increases susceptibility to colitis and colitis-induced colorectal cancer via GPR15-independent mechanisms, while mediating GPR15-dependent T cell migration to the large intestine. Mucosal Immunol. 2025 Aug 13
• All: 1 reference(s)