All Phenotypes Gpr15lg<em1Darl> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpr15lg^em1Darl/Gpr15lg^em1Darl	involves: C57BL/6	MGI:8276515
cx2	Gpr15^tm1.1Litt/Gpr15^tm1.1Litt Gpr15lg^em1Darl/Gpr15lg^em1Darl	involves: 129P2/OlaHsd * C57BL/6	MGI:8276516
cx3	Gpr15lg^em1Darl/Gpr15lg^em1Darl Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:8276518

Allelic Composition	Gpr15lg^em1Darl/Gpr15lg^em1Darl
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr15lg^em1Darl mutation (0 available); any Gpr15lg mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

decreased susceptibility to induced colitis ( J:371435 )

• resistant to DSS induced weight loss

immune system

immune system phenotype ( J:371435 )

N	• no differences in immune cell trafficking or FITC-dextran translocation at steady state

impaired leukocyte migration ( J:371435 )

• in a competitive T cell homing assay T cells expressing GPR15 fail to preferentially home to the large intestine or proximal and distal colon unlike in heterozygous mice

decreased susceptibility to induced colitis ( J:371435 )

• resistant to DSS induced weight loss

decreased T cell number ( J:371435 )

• decrease in the frequency of GPR15-GFP+ T cells in the large intestine at steady state

hematopoietic system

impaired leukocyte migration ( J:371435 )

• in a competitive T cell homing assay T cells expressing GPR15 fail to preferentially home to the large intestine or proximal and distal colon unlike in heterozygous mice

decreased T cell number ( J:371435 )

• decrease in the frequency of GPR15-GFP+ T cells in the large intestine at steady state

cellular

impaired leukocyte migration ( J:371435 )

• in a competitive T cell homing assay T cells expressing GPR15 fail to preferentially home to the large intestine or proximal and distal colon unlike in heterozygous mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

increased intestinal crypt stem cell proliferation ( J:371435 )

• in the large intestine relative to controls lacking expression of only Gpr15

abnormal large intestine crypts of Lieberkuhn morphology ( J:371435 )

• increased crypt length, particularly in the mid and distal colon, relative to controls lacking expression of only Gpr15

• no difference in length is seen in the small intestine

decreased susceptibility to induced colitis ( J:371435 )

• nearly completely protected from DSS-induced colitis with no loss of weight and fully intact crypt architecture unlike in controls lacking expression of only Gpr15

• however, no protection from trinitrobenzene sulfonic acid (TNBS)-induced colitis is seen indicating the difference may the result of changes in responses to epithelial cell damage

• reduced numbers of immune cells in the intestines following DSS induced colitis

neoplasm

decreased incidence of tumors by chemical induction ( J:371435 )

• following DSS-induced colitis double null mice show fewer adenomas and high grade adenomas relative to controls lacking expression of only Gpr15

immune system

decreased susceptibility to induced colitis ( J:371435 )

• nearly completely protected from DSS-induced colitis with no loss of weight and fully intact crypt architecture unlike in controls lacking expression of only Gpr15

• however, no protection from trinitrobenzene sulfonic acid (TNBS)-induced colitis is seen indicating the difference may the result of changes in responses to epithelial cell damage

• reduced numbers of immune cells in the intestines following DSS induced colitis

cellular

increased intestinal crypt stem cell proliferation ( J:371435 )

• in the large intestine relative to controls lacking expression of only Gpr15

endocrine/exocrine glands

abnormal large intestine crypts of Lieberkuhn morphology ( J:371435 )

• increased crypt length, particularly in the mid and distal colon, relative to controls lacking expression of only Gpr15

• no difference in length is seen in the small intestine

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:371435 )

• following DSS-induced colitis double null mice show fewer adenomas and high grade adenomas relative to controls lacking expression of only Gpr15

Allelic Composition	Gpr15lg^em1Darl/Gpr15lg^em1Darl Lgr5^{tm1(cre/ERT2)Cle}/Lgr5⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpr15lg^em1Darl mutation (0 available); any Gpr15lg mutation (7 available)
Lgr5^{tm1(cre/ERT2)Cle} mutation (1 available); any Lgr5 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:371435 )

N	• no difference in the number of LGR5+ intestinal stem cells

increased intestinal crypt stem cell proliferation ( J:371435 )

• isolated LGR5+ stem cells form larger organoids indicating increased proliferation

cellular

increased intestinal crypt stem cell proliferation ( J:371435 )

• isolated LGR5+ stem cells form larger organoids indicating increased proliferation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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