Rr695571^tm1Dlsi
Targeted Allele Detail

Summary

• Symbol: Rr695571^tm1Dlsi
• Name: regulatory region 695571; targeted mutation 1, Debra L Silver
• MGI ID: MGI:8237986
• Synonyms: Mm-HARE5^Hs
• Gene: Rr695571 Location: unknown Genetic Position: Chr18, Syntenic
• Alliance: Rr695571^tm1Dlsi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:366779
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 x C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, Modified regulatory region)
• Mutations: Insertion, Intergenic deletion
• Mutation details: The mouse Fzd8 enhancer (human accelerated region HARE5, GRCm39:chr18:8871184-8872412) was replaced with the human equivalent (GRCh38:chr10:35949193-35950411) and loxP sites were inserted up- and downstream. In homozygous mice, Fzd8 transcription in embryonic brain cortex increased by 25%. (J:366779)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr695571 Mutation: 0 strains or lines available

References

• Original: J:366779 Liu J, et al., A human-specific enhancer fine-tunes radial glia potency and corticogenesis. Nature. 2025 May 14
• All: 1 reference(s)