Rr695571 Other Genome Feature Detail

Summary

• Symbol
  Rr695571
• Name
  regulatory region 695571
• Synonyms
  HARE5

• Feature Type
  enhancer
• IDs
  MGI:8237983

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.
• J:366779: chr18:8871182-8872410 (NCBIm37) chr18:8871184-8872412 (GRCm39)

• Genetic Map
  Chromosome 18, Syntenic

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  7 phenotypes from 1 allele in 2 genetic backgrounds
  1 phenotype reference
  

• All Mutations and Alleles
  1
• Targeted
  1
• Find Mice (IMSR)
  0 strains or lines available

Deletion of this Fzd8 enhancer leads to smaller cerebral cortex and reduced Fzd8 expression, while replacing it with the human ortholog leads to larger cerebral cortex and changes to radial glial cell proliferation and differentiation and increased Fzd8 expression.

References

• Summaries
  All 2

  Phenotypes 1
• Earliest
  J:366779 Liu J, et al., A human-specific enhancer fine-tunes radial glia potency and corticogenesis. Nature. 2025 May 14;