Slc41a1^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Slc41a1^tm1.1Geno
• Name: solute carrier family 41, member 1; targeted mutation 1.1, GenOway
• MGI ID: MGI:7608072
• Synonyms: A1^-
• Gene: Slc41a1 Location: Chr1:131755236-131776601 bp, + strand Genetic Position: Chr1, 57.2 cM
• Alliance: Slc41a1^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:304109
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT-flanked neomycin selection cassette and second loxP site were inserted downstream of exon 6. Cre-mediated recombination removed exons 2-6 and the neomycin selection cassette. Splicing of exons 2 to 7 led to a frame shift, resulting in a premature stop codon in exon 8. (J:304109)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc41a1 Mutation: 33 strains or lines available

References

• Original: J:304109 Tatarkova Z, et al., Dietary Mg(2+) Intake and the Na(+)/Mg(2+) Exchanger SLC41A1 Influence Components of Mitochondrial Energetics in Murine Cardiomyocytes. Int J Mol Sci. 2020 Nov 3;21(21):8221
• All: 2 reference(s)