Analysis Tools
cellular
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• mice show a smaller decrease in aconitate hydratase (ACON) and isocitrate dehydrogenase (ICDH) activity (thus have increased ACON and ICDH activity) in cardiac mitochondria when fed a low magnesium diet than in wild-type mice, indicating partial rescue of the negative effects of magnesium starvation on the Krebs cycle enzymes
• however, no differences in alpha-ketoglutarate dehydrogenase (KGDH) activity are seen compared to wild-type mice when fed a low magnesium diet
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• irrespective of low or normal magnesium diet, higher electron transport chain complex I and complex III activity and decreased complex II activity is seen in cardiac mitochondria compared to wild-type controls
• mice fed a chronic low magnesium diet show an increase in electron transport chain complex IV (cytochrome c oxidase) activity and complex V (F1F0-ATPase) activity in cardiac mitochondria compared to mutant mice fed a normal magnesium diet or wild-type mice fed a low magnesium diet
• mice fed a normal magnesium diet show lower electron transport chain complex IV activity in cardiac mitochondria than wild-type mice
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homeostasis/metabolism
| N |
• mice do not show altered magnesium homeostasis, with normal serum and urine magnesium levels, regardless of normal or low-magnesium diet
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renal/urinary system
| N |
• mice exhibit normal kidney morphology with well-developed tubular and glomerular structures and absence of fibrosis and infiltration of inflammatory cells, and normal urine volume and fecal weight
• administration of a low-magnesium diet does not alter kidney morphology compared with mice fed a normal diet
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