Rr124128^tm1.2Jfer
Targeted Allele Detail

Summary

• Symbol: Rr124128^tm1.2Jfer
• Name: regulatory region 124128; targeted mutation 1.2, Jorge Ferrer
• MGI ID: MGI:7431276
• Synonyms: Haster^-
• Gene: Rr124128 Location: Chr5:115106000-115110601 bp Genetic Position: Chr5, Syntenic
• Alliance: Rr124128^tm1.2Jfer page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:332319
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Rr124128^tm1.2Jfer involves 2 genes/genome features (Hnf1aos1, Hnf1aos2) View all
• Mutation details: An FRT site flanked neomycin resistance gene cassette and a loxP site were inserted upstream of the Hnf1aos1 gene promoter/1st exon and a second loxP site downstream of the Hnf1aos2 gene promoter/1st exon. These exons, promoters and loxP sites are located in Hnf1a intron 1. The neo cassette was removed through subsequent flp-mediated recombination. The ~1.8 kb floxed sequence, containing Hnf1aos1 and Hnf1aos2 promoters and 1st exons, was subsequently deleted through cre-mediated recombination. (J:332319)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr124128 Mutation: 0 strains or lines available

References

• Original: J:332319 Beucher A, et al., The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A. Nat Cell Biol. 2022 Oct;24(10):1528-1540
• All: 1 reference(s)