Tg(CYP2D6)#Gonz
Transgene Detail

Summary

• Symbol: Tg(CYP2D6)#Gonz
• Name: transgene insertion, Frank J Gonzalez
• MGI ID: MGI:6750929
• Synonyms: Tg-CYP2D6
• Transgene: Tg(CYP2D6)#Gonz Location: unknown
• Alliance: Tg(CYP2D6)#Gonz page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CYP2D6)#Gonz expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CYP2D6 (1565)

  Cyp2d9	(MGI:88606)
  Cyp2d10	(MGI:88602)
  Cyp2d11	(MGI:88603)
  Cyp2d12	(MGI:88604)
  Cyp2d22	(MGI:1929474)
  Cyp2d26	(MGI:1923529)
  Cyp2d34	(MGI:2385022)
  Cyp2d40	(MGI:1919004)

  human gene

• Mutation details: The transgene insert comprises the entire human cytochrome P450 family 2 subfamily D member 6 gene, including its regulatory sequences. (J:104020)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:104020 Corchero J, et al., The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse. Mol Pharmacol. 2001 Dec;60(6):1260-7
• All: 11 reference(s)