Lcp1^tm1.1Shcm
Targeted Allele Detail

Summary

• Symbol: Lcp1^tm1.1Shcm
• Name: lymphocyte cytosolic protein 1; targeted mutation 1.1, Sharon Celeste Morley
• MGI ID: MGI:6359802
• Synonyms: LPL^fl
• Gene: Lcp1 Location: Chr14:75368570-75468282 bp, + strand Genetic Position: Chr14, 39.63 cM
• Alliance: Lcp1^tm1.1Shcm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and an FRT site flanked neomycin resistance gene cassette plus a second loxP site were inserted into intron 2. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 2 floxed. (J:238746)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lcp1 Mutation: 41 strains or lines available

Notes

The version of this allele that contains the neomycin selection cassette, Lcp1^tm1Shcm, has been analyzed.

References

• Original: J:238746 Todd EM, et al., Alveolar macrophage development in mice requires L-plastin for cellular localization in alveoli. Blood. 2016 Dec 15;128(24):2785-2796
• All: 2 reference(s)