Inava^tm1.1Itl
Targeted Allele Detail

Summary

• Symbol: Inava^tm1.1Itl
• Name: innate immunity activator; targeted mutation 1,1, inGenious Targeting Laboratory
• MGI ID: MGI:6356370
• Synonyms: C1orf106^-
• Gene: Inava Location: Chr1:136141269-136162002 bp, - strand Genetic Position: Chr1, 59.61 cM, cytoband F
• Alliance: Inava^tm1.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257317
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-8 were replaced with a loxP-flanked neomycin selection cassette. The neo cassette was removed via Cre-mediated recombination. Immunoblot analysis confirmed the absence of protein expression in intestinal epithelial monolayers derived from organoids and intestinal epithelial cells isolated from the colon of homozygous mutant mice. (J:257317)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Inava Mutation: 38 strains or lines available

References

• Original: J:257317 Mohanan V, et al., C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions. Science. 2018 Mar 9;359(6380):1161-1166
• All: 1 reference(s)