Del(18Pcdhb)4Tyag
Targeted Allele Detail

Summary

• Symbol: Del(18Pcdhb)4Tyag
• Name: deletion, Chr 18, Takeshi Yagi 4
• MGI ID: MGI:6331277
• Synonyms: Del(18Pcdhb)1Tyag, Del4Tyag, Pcdhb^del
• Gene: Del(18Pcdhb)4Tyag Location: unknown Genetic Position: Chr18, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244163
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Del(18Pcdhb)4Tyag involves 23 genes/genome features (Pcdhb, Pcdhb1, Pcdhb2 ...) View all
• Mutation details: This allele follows the meiotic cre-mediated recombination between the Pcdhb^tm1Tyag and Pcdhb^tm2Tyag alleles. The Pcdhb^tm1Tyag allele has a loxP and FRT site flanked neomycin resistance gene cassette inserted upstream of the first gene, Pcdhb1, in the cluster. The Pcdhb^tm2Tyag allele has a loxP and FRT site flanked neomycin resistance gene cassette inserted downstream of the last gene, Pcdhb22, in the cluster. Recombination between the two results in the complete deletion of the Pcdhb cluster plus the two neo cassettes. (J:244163)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(18Pcdhb)4Tyag Mutation: 0 strains or lines available

References

• Original: J:244163 Hasegawa S, et al., Distinct and Cooperative Functions for the Protocadherin-alpha, -beta and -gamma Clusters in Neuronal Survival and Axon Targeting. Front Mol Neurosci. 2016;9:155
• All: 1 reference(s)