Adamts18^tm1.1Wzha
Targeted Allele Detail

Summary

• Symbol: Adamts18^tm1.1Wzha
• Name: ADAM metallopeptidase with thrombospondin type 1 motif 18; targeted mutation 1.1, Wei Zhang
• MGI ID: MGI:6148036
• Gene: Adamts18 Location: Chr8:114423758-114575370 bp, - strand Genetic Position: Chr8, 59.65 cM
• Alliance: Adamts18^tm1.1Wzha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:258487
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and FRT flanked pgk-neo cassette were inserted upstream of exon 5 and a loxP site was inserted downstream of exon 6 via homologous recombination. Cre mediated recombination removed the neo cassette and exons 5 and 6. Absence of expression in the brain was confirmed by immunohistochemistry. (J:258487)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adamts18 Mutation: 66 strains or lines available

References

• Original: J:258487 Lu T, et al., Adamts18 deficiency promotes colon carcinogenesis by enhancing beta-catenin and p38MAPK/ERK1/2 signaling in the mouse model of AOM/DSS-induced colitis-associated colorectal cancer. Oncotarget. 2017 Mar 21;8(12):18979-18990
• All: 9 reference(s)