Tspan7^tm1Mpass
Targeted Allele Detail

Summary

• Symbol: Tspan7^tm1Mpass
• Name: tetraspanin 7; targeted mutation 1, Maria Passafaro
• MGI ID: MGI:6095166
• Gene: Tspan7 Location: ChrX:10351397-10462844 bp, + strand Genetic Position: ChrX, 4.85 cM, cytoband A1.3-A2
• Alliance: Tspan7^tm1Mpass page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247598
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ neomycin resistance cassette replaced the first coding exon. Western blot analysis confirmed the absence of protein expression in the brain. (J:247598)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tspan7 Mutation: 9 strains or lines available

References

• Original: J:247598 Murru L, et al., Pharmacological Modulation of AMPAR Rescues Intellectual Disability-Like Phenotype in Tm4sf2-/y Mice. Cereb Cortex. 2017 Nov 01;27(11):5369-5384
• All: 2 reference(s)