Phenotypes associated with this allele

• Allele Symbol: Tspan7^tm1Mpass
• Allele Name: targeted mutation 1, Maria Passafaro
• Allele ID: MGI:6095166
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tspan7^tm1Mpass/Tspan7^tm1Mpass	Not Specified	MGI:6095180

Genotype
MGI:6095180

hm1

• Allelic Composition: Tspan7^tm1Mpass/Tspan7^tm1Mpass
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal hippocampus neuron morphology ( J:247598 )

• reduced length and thickness of postsynaptic densities and volume in culture from young and adult mice

• however, the volume of spine heads is normal

decreased dendritic spine density ( J:247598 )

• reduced spine density in the CA1 region of adult mice

• however, spine density in the apical dendrites is normal in young mice

abnormal action potential ( J:247598 )

• impaired for action potential threshold, minimum current intensity and action potential firing frequency

reduced long-term potentiation ( J:247598 )

• severely impaired at CA1 synapses

abnormal miniature excitatory postsynaptic currents ( J:247598 )

• reduced amplitude and frequency of AMPAR-mediated miniature excitatory postsynaptic currents

• however, paired pulse ratio experiments revealed normal neurotransmitter release probability and mice exhibit normal GABA-mediated miniature inhibitory postsynaptic currents

behavior/neurological

impaired contextual conditioning behavior ( J:247598 )

• impaired associating memory

• however, fear-related behavior acquisition is normal

impaired spatial learning ( J:247598 )

• increased latency to finding the platform in a water maze

• decreased time swimming in the quadrant that previously housed the platform

abnormal spatial working memory ( J:247598 )

• reduced exploration of a displaced object compared with wild-type mice

abnormal response to novel object ( J:247598 )

• reduced discrimination with decreased exploration of a novel object compared with wild-type mice