Fermt2^tm1.1Gxo
Targeted Allele Detail

Summary

• Symbol: Fermt2^tm1.1Gxo
• Name: fermitin family member 2; targeted mutation 1.1, Guozhi Xiao
• MGI ID: MGI:5788419
• Synonyms: Kindlin-2^fl, Kindlin2^flox
• Gene: Fermt2 Location: Chr14:45696252-45767575 bp, - strand Genetic Position: Chr14, 22.97 cM
• Alliance: Fermt2^tm1.1Gxo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224370
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 5. An additional loxP site was inserted downsteam of exon 6. Flp-mediated recombination removed the selection cassette and left exons 5 and 6 floxed. (J:224370)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	23 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fermt2 Mutation: 31 strains or lines available

References

• Original: J:224370 Wu C, et al., Kindlin-2 controls TGF-beta signalling and Sox9 expression to regulate chondrogenesis. Nat Commun. 2015;6:7531
• All: 12 reference(s)