Elk3^tm1.2Ics
Targeted Allele Detail

Summary

• Symbol: Elk3^tm1.2Ics
• Name: ELK3, member of ETS oncogene family; targeted mutation 1.2, Mouse Clinical Institute
• MGI ID: MGI:5781314
• Synonyms: Elk3^-
• Gene: Elk3 Location: Chr10:93083276-93146997 bp, - strand Genetic Position: Chr10, 48.04 cM, cytoband C-D1
• Alliance: Elk3^tm1.2Ics page

Delayed retinal angiogenesis during early postnatal stages in Elk3^tm1.2Ics/Elk3^tm1.2Ics mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221521
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 1. (J:221521)

Generation of the Elk3^tm1.1Ics and Elk3^tm1.2Ics alleles

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elk3 Mutation: 19 strains or lines available

References

• Original: J:221521 Weinl C, et al., Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae. PLoS One. 2014;9(9):e107048
• All: 1 reference(s)