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| Caption | Delayed retinal angiogenesis during early postnatal stages in Elk3tm1.2Ics/Elk3tm1.2Ics [Elk3(-/-)] mice. (A) IsolectinB4 staining of flat-mounts of retinae from P4 wild-type (WT) and mutant mice. The red lines outline the whole retinal area, the yellow lines the areas covered by blood vessels. (B) Quantitation of retinal area covered by blood vessels (% vascularization) at P4. (C) Higher magnification of the angiogenic front in P4 control and mutant knockout retinae. (D) IsolectinB4 staining of retinal flat-mounts of a P6 WT and mutant mouse. The red arrow points towards delayed angiogenic front in the mutant retina. (E) Quantitation of retinal area covered by blood vessels (% vascularization) at P6. (F) Higher magnification of the angiogenic front in P6 control and mutant retinae. (G) IsolectinB4 staining of retinal flat-mounts from P8 WT and mutant mice. The red arrow points towards the delayed angiogenic front in the mutant retina. (H) Quantitation of retinal area covered by blood vessels (% vascularization) at P8. (I) Higher magnification of the angiogenic front in P8 control and mutant retinae. All quantitation data are normalized to the control = 100%. The data shown are means +/- s.e.m. Statistical significance using Student's t-test is indicated with * p<0.05 ** p<0.01 *** p<0.001. Scale bar in (A, D, G) 1000 um, in (C, F, I) 100 um. | ||||
| Copyright | This image is from Weinl C, PLoS One 2014;9(9):e107048, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:221521 | ||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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