Cldn8^tm1.1Jhou
Targeted Allele Detail

Summary

• Symbol: Cldn8^tm1.1Jhou
• Name: claudin 8; targeted mutation 1.1, Jianghui Hou
• MGI ID: MGI:5750892
• Synonyms: claudin-8^flox, CLDN8^fl, CLDN8^flox
• Gene: Cldn8 Location: Chr16:88357716-88360071 bp, - strand Genetic Position: Chr16, 51.22 cM
• Alliance: Cldn8^tm1.1Jhou page

Delocalization of claudin-4 in the tight junction of Cldn8^tm1.1Jhou/Cldn8^tm1.1Jhou Tg(Aqp2-cre)1Dek/0 kidney collecting duct

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220813
• Parent Cell Line: EDJ22 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

Allele Type: Targeted (Conditional ready) Mutation: Insertion Mutation details: The sole exon was flanked with loxP sites and an FRT flanked neo cassette was inserted 5' of the exon via homologous recombination. Flp mediated recombination removed the neo cassette. (J:220813)

Generation of the Cldn8^tm1.1Jhou allele

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cldn8 Mutation: 30 strains or lines available

References

• Original: J:220813 Gong Y, et al., KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4340-5
• All: 1 reference(s)