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| Caption | Generation of the Cldn8tm1.1Jhou allele. A. The diagram showing the wild-type CLDN8 locus, the targeting construct, and the targeted locus. On the targeting construct, the 5'-arm homologous region is 2.6kb long; the 3'-arm homologous region is 6.0kb long. The exon 1 (only exon) of claudin-8 is flanked by two loxP sites. The PGK-neo expression cassette is flanked by two FRT sites. Once correctly targeted, the PGK-neo cassette will be removed by the flp enzyme. | ||||
| Copyright | This image is from Gong Y, Proc Natl Acad Sci U S A 2015 Apr 7;112(14):4340-5. Copyright 2015 National Academy of Sciences, U.S.A. J:220813 | ||||
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Associated Alleles |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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