Dock8^rs37224966-T
Spontaneous Allele Detail

Summary

• Symbol: Dock8^rs37224966-T
• Name: dedicator of cytokinesis 8; rs37224966 SNP allele with the T variant
• MGI ID: MGI:5749379
• Gene: Dock8 Location: Chr19:24976898-25179796 bp, + strand Genetic Position: Chr19, 19.91 cM
• Alliance: Dock8^rs37224966-T page

Mutation origin

• Strain of Origin: C3H/HeJ

Mutation description

• Allele Type: Spontaneous (Hypomorph)
• Mutation: Single point mutation
• Mutation details: A C-to-T point mutation located in exon 27 results in an Arg to Trp substitution at position 1094 (p.R1094W). Homozygous mice show a mild reduction in protein levels in bone marrow derived dendritic cells. (J:220239)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dock8 Mutation: 101 strains or lines available

References

• Original: J:220239 Krishnaswamy JK, et al., Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration. Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3056-61
• All: 1 reference(s)