Dp(16Lipi-Zbtb21)1TybEmcf
Targeted Allele Detail

Summary

• Symbol: Dp(16Lipi-Zbtb21)1TybEmcf
• Name: duplication, Chr 16, Victor Tybulewicz and Elizabeth M C Fisher 1
• MGI ID: MGI:5703798
• Synonyms: Dp(16)1TybEmcf, Dp1Tyb
• Gene: Dp(16Lipi-Zbtb21)1TybEmcf Location: unknown Genetic Position: Chr16, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:227899
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted
• Mutation: Duplication
• Dp(16Lipi-Zbtb21)1TybEmcf involves 6 genes/genome features (Gm41503, Chodl, Map3k7cl ...) View all
• Mutation details: MICER vectors MHPP352i17 (coordinates of homology region 16:74930370-16:74937378 Mb; mouse assembly GRCm38/mm10) and MHPN352i16 (16:97977263-16:97982380 Mb) were used to insert loxP sites proximal to Lipi and distal to Zbtb21. Cre-mediated recombination duplicated the 23 Mb floxed by loxP sites. (J:227899)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Dp(16Lipi-Zbtb21)1TybEmcf Mutation: 3 strains or lines available

References

• Original: J:227899 Lana-Elola E, et al., Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel. Elife. 2016 Jan 14;5:e11614
• All: 13 reference(s)