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Zbtb21 Gene Detail
Summary
  • Symbol
    Zbtb21
  • Name
    zinc finger and BTB domain containing 21
  • Synonyms
    5430437K12Rik, B430213I24Rik, mKIAA1227, Zfp295, Znf295
  • Feature Type
    protein coding gene
  • IDs
    MGI:1927240
    NCBI Gene: 114565
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:97746993-97763850 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 57.75 cM, cytoband C3-4
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1927240
 protein coding gene Chr16:97744557-97763850 (-)
129S1/SvImJ ENSMUSG00200016653
 protein coding gene Chr16:94680609-94696342 (-)
A/J ENSMUSG00195015434
 protein coding gene Chr16:94439233-94454967 (-)
AKR/J ENSMUSG00220009100
 protein coding gene Chr16:94700737-94716462 (-)
BALB/cJ ENSMUSG00180001115
 protein coding gene Chr16:94513338-94529042 (-)
C3H/HeJ ENSMUSG00175002747
 protein coding gene Chr16:94849970-94865703 (-)
C57BL/6NJ ENSMUSG00215018948
 protein coding gene Chr16:94655910-94671642 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021014
 protein coding gene Chr16:92550005-92565146 (-)
CAST/EiJ ENSTCUG00005012590
 protein coding gene Chr16:94245454-94261102 (-)
CBA/J ENSMUSG00210017451
 protein coding gene Chr16:94747579-94763316 (-)
DBA/2J ENSMUSG00185003501
 protein coding gene Chr16:94695506-94711241 (-)
FVB/NJ ENSMUSG00205013257
 protein coding gene Chr16:94472114-94487849 (-)
JF1/MsJ ENSUMUG00000015845
 protein coding gene Chr16:94831195-94846964 (-)
LP/J ENSMUSG00230026055
 protein coding gene Chr16:97227021-97242756 (-)
NOD/ShiLtJ ENSMUSG00190003723
 protein coding gene Chr16:94659369-94675104 (-)
NZO/HlLtJ ENSMUSG00225030540
 protein coding gene Chr16:100342371-100358089 (-)
PWK/PhJ ENSLUMG00010014794
 protein coding gene Chr16:94480221-94496567 (-)
SPRET/EiJ ENSMSPG00010019316
 protein coding gene Chr16:95605743-95620966 (-)
WSB/EiJ ENSIUOG00005013645
 protein coding gene Chr16:94624326-94640055 (-)



Homology
more
  • Human Ortholog
    ZBTB21, zinc finger and BTB domain containing 21
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZBTB21, zinc finger and BTB domain containing 21
  • Synonyms
    ZNF295
  • Links
    NCBI Gene ID: 49854
    UniProt: Q9ULJ3

  • Chr Location
    21q22.3; chr21:41986831-42010387 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show little to no synaptic or cognitive deficits.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    658
  • Tissues
    50
  • cDNA Data
    35
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 114565 NCBI Gene Model | MGI Sequence Detail 16858 C57BL/6J ±  kb
    transcript NM_175428 RefSeq | MGI Sequence Detail 6011 C57BL/6  
    polypeptide NP_780637 RefSeq | MGI Sequence Detail 1094 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 1
      cDNA 36
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1918624, MGI:2444503
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 5
      Gene Ontology 2
      Phenotypes 15
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory