Per2^Edo
Chemically induced Allele Detail

Summary

• Symbol: Per2^Edo
• Name: period circadian clock 2; early doors
• MGI ID: MGI:5642054
• Gene: Per2 Location: Chr1:91343699-91387028 bp, - strand Genetic Position: Chr1, 46.13 cM, cytoband C5
• Alliance: Per2^Edo page

Mutation origin

• Strain of Origin: BALB/c
• Project Collection: Harwell ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU) (Constitutively active)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a point mutation that results in ithe amino acid substitution of asparagine for isoleucine at position 324 (I324N). (J:231000)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Per2 Mutation: 72 strains or lines available

References

• Original: J:231000 Militi S, et al., Early doors (Edo) mutant mouse reveals the importance of period 2 (PER2) PAS domain structure for circadian pacemaking. Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):2756-61
• All: 1 reference(s)