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Targeted Allele Detail
Symbol: Fosbtm1.1Yun
Name: FBJ osteosarcoma oncogene B; targeted mutation 1.1, Yusaku Nakabeppu
MGI ID: MGI:5634956
Synonyms: Fosbd
Gene: Fosb  Location: Chr7:19036621-19043970 bp, - strand  Genetic Position: Chr7, 9.56 cM, cytoband A2-B1
Alliance: Fosbtm1.1Yun page
Germline Transmission:  Earliest citation of germline transmission: J:220448
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Modified isoform(s))
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsA floxed neo cassette was inserted in intron 3 and the sequence encoding the alternative splicing donor site for the exonic intron in exon 4 was replaced with tandem stop codons (GTG, AGA to TAG, TGA) via homologous recombination. This prevents the expression of the short transcript but allows expression of the longer transcript that encodes two isoforms (deltaFosb and delta2deltaFosb). Cre-mediated recombination removed the neo cassette. (J:220449)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fosb Mutation:  18 strains or lines available
Original:  J:220449 Ohnishi YN, et al., Antagonistic regulation of cell-matrix adhesion by FosB and DeltaFosB/Delta2DeltaFosB encoded by alternatively spliced forms of fosB transcripts. Mol Biol Cell. 2008 Nov;19(11):4717-29
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory