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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fosbtm1.1Yun
targeted mutation 1.1, Yusaku Nakabeppu
MGI:5634956
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fosbtm1.1Yun/Fosbtm1.1Yun B6.129S-Fosbtm1.1Yun MGI:5691444
ht2
 		Fosbtm1.1Yun/Fosb+ B6.129S-Fosbtm1.1Yun MGI:5691445


Genotype
MGI:5691444
hm1
Allelic
Composition		 Fosbtm1.1Yun/Fosbtm1.1Yun
Genetic
Background		 B6.129S-Fosbtm1.1Yun
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosbtm1.1Yun mutation (1 available); any Fosb mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased exploration in new environment ( J:220448 )
• open field exploratory behavior is greater than controls at day 1
• although exploratory behavior declines by day 2, it remains greater than in controls
decreased anxiety-related response ( J:220448 )
• stayed significantly longer in the open arms of an elevated maze than do controls
abnormal locomotor activation ( J:220448 )
• significantly greater locomotor activity than controls or heterozygotes when housed alone for three days
increased locomotor activity ( J:220448 )
• greater hyperlocomotion in the active phase of the circadian cycle than seen in other genotypes
• transient hyperlocomotion induced by methylphenidate (MPH)




Genotype
MGI:5691445
ht2
Allelic
Composition		 Fosbtm1.1Yun/Fosb+
Genetic
Background		 B6.129S-Fosbtm1.1Yun
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fosbtm1.1Yun mutation (1 available); any Fosb mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased exploration in new environment ( J:220448 )
• open field exploratory behavior is greater than controls at day 1
• although exploratory behavior declines by day 2, it remains greater than in controls
decreased anxiety-related response ( J:220448 )
• stayed significantly longer in the open arms of an elevated maze than do controls
abnormal locomotor activation ( J:220448 )
• significantly greater locomotor activity than controls or heterozygotes when housed alone for three days
increased locomotor activity ( J:220448 )
• greater hyperlocomotion in the active phase of the circadian cycle than seen in other genotypes
• transient hyperlocomotion induced by methylphenidate (MPH)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory