Igk^{tm1.1(IgkAb2-1.4)Bbo}
Targeted Allele Detail

Summary

• Symbol: Igk^{tm1.1(IgkAb2-1.4)Bbo}
• Name: immunoglobulin kappa chain complex; targeted mutation 1.1, Bjarne Bogen
• MGI ID: MGI:5617053
• Synonyms: VJk^aId
• Gene: Igk Location: Chr6:67532620-70703738 bp, + strand Genetic Position: Chr6, 30.89 cM, cytoband F1-pter

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209958
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Igk^{tm1.1(IgkAb2-1.4)Bbo} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Igk (MGI:96494)

• Mutation details: The J kappa 1-5 regions were replaced with a floxed neo cassette and the rearranged VJ kappa region of the L chain of the anti-idiotope (Id+ M315 Ig) mAb Ab2-1.4. Cre mediated recombination removed the neo cassette. (J:209958)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igk Mutation: 33 strains or lines available

References

• Original: J:209958 Jacobsen J, et al., Naive idiotope-specific B and T cells collaborate efficiently in the absence of dendritic cells. J Immunol. 2014 May 1;192(9):4174-83
• All: 1 reference(s)