Lck^m3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Lck^m3Btlr
• Name: lymphocyte protein tyrosine kinase; mutation 3, Bruce Beutler
• MGI ID: MGI:5615964
• Synonyms: lockdown
• Gene: Lck Location: Chr4:129442142-129467415 bp, - strand Genetic Position: Chr4, 63.26 cM, cytoband distal
• Alliance: Lck^m3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a G to A transition at base pair 129,558,127 (v38) on chromosome 4, or base pair 15,515 in the GenBank genomic region NC_000070. The mutation corresponds to residue 149 in the NM_001162432 mRNA sequence in exon 2 of 13 total exons, or at position 191 bp of the NM_001162433 mRNA sequence in exon 2 of 13 total exons, or at position 1,050 of the NM_010693 mRNA sequence in exon 1 of 12 total exons. The mutation results in a cysteine to tyrosine substitution at position 31 (C31Y) in the protein isoform encoded by NM_001162432 and a cysteine to tyrosine substitution at position 25 (C25Y) in the protein isoforms encoded by NM_001162433 and NM_010693. (J:217863)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lck Mutation: 93 strains or lines available

References

• Original: J:217863 Yue T, et al., Mutagenetix entry for lockdown. MGI Direct Data Submission. 2015
• All: 1 reference(s)