Phenotypes associated with this allele

• Allele Symbol: Lck^m3Btlr
• Allele Name: mutation 3, Bruce Beutler
• Allele ID: MGI:5615964
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lck^m3Btlr/Lck^m3Btlr	C57BL/6J-Lck^m3Btlr	MGI:5615985

Genotype
MGI:5615985

hm1

• Allelic Composition: Lck^m3Btlr/Lck^m3Btlr
• Genetic Background: C57BL/6J-Lck^m3Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal T cell subpopulation ratio ( J:217863 )

• an increase in the B:T cell ratio as well as a decrease in the CD4+ to CD8+ T cell ratio

decreased single-positive T cell number ( J:217863 )

• a diminished frequency of CD4+ T cells and CD4+ T cells in CD3+ T cells

increased activated T cell number ( J:217863 )

• some mice exhibit an increase in the CD44 mean fluorescence intensity on total T cells and on CD8+ T cell

increased single-positive T cell number ( J:217863 )

• an increased frequency of CD8+ T cells in CD3+ cells

hematopoietic system

abnormal T cell subpopulation ratio ( J:217863 )

• an increase in the B:T cell ratio as well as a decrease in the CD4+ to CD8+ T cell ratio

decreased single-positive T cell number ( J:217863 )

• a diminished frequency of CD4+ T cells and CD4+ T cells in CD3+ T cells

increased activated T cell number ( J:217863 )

• some mice exhibit an increase in the CD44 mean fluorescence intensity on total T cells and on CD8+ T cell

increased single-positive T cell number ( J:217863 )

• an increased frequency of CD8+ T cells in CD3+ cells