Rax^{tm1.1(cre/ERT2)Sbls}
Targeted Allele Detail

Summary

• Symbol: Rax^{tm1.1(cre/ERT2)Sbls}
• Name: retina and anterior neural fold homeobox; targeted mutation 1.1, Seth Blackshaw
• MGI ID: MGI:5558909
• Synonyms: Rax-CreER^T2
• Gene: Rax Location: Chr18:66067710-66072160 bp, - strand Genetic Position: Chr18, 39.03 cM
• Alliance: Rax^{tm1.1(cre/ERT2)Sbls} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207455
• Parent Cell Line: MC1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Rax^{tm1.1(cre/ERT2)Sbls} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Rax (MGI:109632)

• Mutation details: A cre/ERT2 cassette followed by an Frt-flanked PGK-neo selection marker was inserted downstream of the start ATG of the Rax gene following homologous recombination of a targeting vector in ES cells. The PGK-neo was excised from the germline by mating animals with Flp-expressing mice. (J:207455)

Generation of Rax^{tm1.1(cre/ERT2)Sbls}.

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Rax (mouse) Summary of all recombinase alleles driven by Rax. Comparative matrix view of recombinase activities Alliance mouse Rax gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rax Mutation: 16 strains or lines available

References

• Original: J:207455 Pak T, et al., Rax-CreERT2 Knock-In Mice: A Tool for Selective and Conditional Gene Deletion in Progenitor Cells and Radial Glia of the Retina and Hypothalamus. PLoS One. 2014;9(4):e90381
• All: 16 reference(s)