All Phenotypes Rax<tm1.1(cre/ERT2)Sbls> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rax^{tm1.1(cre/ERT2)Sbls}
targeted mutation 1.1, Seth Blackshaw
MGI:5558909

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rax^{tm1.1(cre/ERT2)Sbls}/Rax⁺ Yap1^tm1Hmc/Yap1^tm1Hmc	involves: 129S6/SvEvTac * C57BL/6NCrl	MGI:6716882

Allelic Composition	Rax^{tm1.1(cre/ERT2)Sbls}/Rax⁺ Yap1^tm1Hmc/Yap1^tm1Hmc
Genetic Background	involves: 129S6/SvEvTac * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rax^{tm1.1(cre/ERT2)Sbls} mutation (1 available); any Rax mutation (16 available)
Yap1^tm1Hmc mutation (0 available); any Yap1 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal retina morphology ( J:304126 )

• S-opsin and M-cone opsins are reduced in the retina, with S-opsin signal drastically decreased dorsally while M-opsin almost absent ventrally

• however, the number of cones is not changed

retina gliosis ( J:304126 )

• 4-OHT-treated mice show reactive gliosis in the retina at 12 months of age

nervous system

abnormal glial cell physiology ( J:304126 )

• marker analysis of mice treated with 4-hydroxy-tamoxifen (4-OHT) at P10 shows Muller cell homeostasis dysfunction at 12 months of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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