Myh9tm1.1Dash
Targeted Allele Detail
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Symbol: |
Myh9tm1.1Dash |
Name: |
myosin, heavy polypeptide 9, non-muscle; targeted mutation 1.1, Tadashi Matsushita |
MGI ID: |
MGI:5551833 |
Synonyms: |
Myh9R702C, R702C+ |
Gene: |
Myh9 Location: Chr15:77644787-77726375 bp, - strand Genetic Position: Chr15, 36.81 cM
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Alliance: |
Myh9tm1.1Dash page
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Abnormal megakaryocytopoiesis in Myh9tm1.1Dash/Myh9+ mice
Show the 3 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:204923
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Parent Cell Line: |
D3 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Nucleotide susbtitutions in exon 16 result in the amino acid substitution of cysteine for arginine at position 702 (R702C). Cre-mediated recombination removed the floxed neomycin resistance cassette inserted upstream of exon 15.
(J:204923)
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Generation of the Myh9tm1.1Dash allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Myh9 Mutation: |
218 strains or lines available
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Original: |
J:204923 Suzuki N, et al., Establishment of mouse model of MYH9 disorders: heterozygous R702C mutation provokes macrothrombocytopenia with leukocyte inclusion bodies, renal glomerulosclerosis and hearing disability. PLoS One. 2013;8(8):e71187 |
All: |
1 reference(s) |
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