Phenotypes associated with this allele

• Allele Symbol: Myh9^tm1.1Dash
• Allele Name: targeted mutation 1.1, Tadashi Matsushita
• Allele ID: MGI:5551833
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myh9^tm1.1Dash/Myh9^tm1.1Dash	involves: 129S2/SvPas * C57BL/6 * CBA	MGI:5551885
ht2	Myh9^tm1.1Dash/Myh9^+	involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA	MGI:5551884

Genotype
MGI:5551885

hm1

• Allelic Composition: Myh9^tm1.1Dash/Myh9^tm1.1Dash
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:204923 )

• despite being present at E12.5, no mice are present at E18.5

Genotype
MGI:5551884

ht2

• Allelic Composition: Myh9^tm1.1Dash/Myh9⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * CBA

Abnormal megakaryocytopoiesis in Myh9^tm1.1Dash/Myh9⁺ mice

mortality/aging

preweaning lethality, complete penetrance ( J:204923 )

• despite being present at E12.5, fewer than expected mice are present at weaning

hematopoietic system

abnormal megakaryocyte differentiation ( J:204923 )

• abnormal proplatelet formation in cultured fetal liver-derived megakaryocytes

abnormal platelet morphology ( J:204923 )

• more than twice the diameter of wild-type cells

abnormal thrombopoiesis ( J:204923 )

• abnormal proplatelet formation in cultured fetal liver-derived megakaryocytes

thrombocytopenia ( J:204923 )

• macrothrombocytopenia

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:204923 )

N • mice exhibit normal bleeding time and clot retraction

albuminuria ( J:204923 )

• severe at 5 weeks

• progressive

hematuria ( J:204923 )

• little from 7 to 20 weeks

renal/urinary system

albuminuria ( J:204923 )

• severe at 5 weeks

• progressive

hematuria ( J:204923 )

• little from 7 to 20 weeks

podocyte foot process effacement ( J:204923 )

glomerulosclerosis ( J:204923 )

• mild segmental sclerosis to global sclerosis

vision/eye

vision/eye phenotype ( J:204923 )

N • mice do not exhibit cataracts

abnormal lens fiber morphology ( J:204923 )

• vacuole formation in the lens fibra at 20 weeks

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:204923 )

N • inner ear morphology is normal

increased or absent threshold for auditory brainstem response ( J:204923 )

cellular

abnormal megakaryocyte differentiation ( J:204923 )

• abnormal proplatelet formation in cultured fetal liver-derived megakaryocytes

immune system

abnormal thrombopoiesis ( J:204923 )

• abnormal proplatelet formation in cultured fetal liver-derived megakaryocytes