Dnmt3b^MommeD14
Chemically induced Allele Detail

Summary

• Symbol: Dnmt3b^MommeD14
• Name: DNA methyltransferase 3B; modifier of murine metastable epialleles, D14
• MGI ID: MGI:5515362
• Synonyms: MommeD14
• Gene: Dnmt3b Location: Chr2:153491370-153529650 bp, + strand Genetic Position: Chr2, 75.79 cM, cytoband A2-A3
• Alliance: Dnmt3b^MommeD14 page

Mutation origin

• Strain of Origin: FVB/NJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T-to-C single point mutation at the 5' splice site of intron 13 is predicted to result in a splicing defect in the mRNA. qRT-PCR and Western analyses showed that the mRNA and protein levels were not grossly affected, suggesting that this allele is a hypomorph. (J:198944, J:201508)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnmt3b Mutation: 50 strains or lines available

References

• Original: J:198944 Youngson NA, et al., No evidence for cumulative effects in a Dnmt3b hypomorph across multiple generations. Mamm Genome. 2013 Jun;24(5-6):206-17
• All: 3 reference(s)