Phenotypes associated with this allele

• Allele Symbol: Dnmt3b^MommeD14
• Allele Name: modifier of murine metastable epialleles, D14
• Allele ID: MGI:5515362
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Dnmt3b^MommeD14/Dnmt3b^MommeD14 Tg(HBA1-GFP)1Ew/0	involves: FVB/N	MGI:5515788
cx2	Dnmt3b^MommeD14/Dnmt3b^tm1Enl Tg(HBA1-GFP)1Ew/0	involves: FVB/N	MGI:5515792

Genotype
MGI:5515788

cx1

• Allelic Composition: Dnmt3b^MommeD14/Dnmt3b^MommeD14; Tg(HBA1-GFP)1Ew/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal epigenetic regulation of gene expression ( J:198944 )

• surviving homozygous mice displayed a higher percentage of GFP-expressing cells than did the heterozygotes

• significantly reduced methylation of transgene DNA in homozygous individuals (28 % of CpGs methylated) compared with wild type littermates (62 % of CpGs methylated), consistent with the change in transcriptional activity

mortality/aging

preweaning lethality, incomplete penetrance ( J:198944 )

• heterozygous intercrosses only resulted in 10% of homozygous offspring instead of the expected 25%

Genotype
MGI:5515792

cx2

• Allelic Composition: Dnmt3b^MommeD14/Dnmt3b^tm1Enl; Tg(HBA1-GFP)1Ew/0
• Genetic Background: involves: FVB/N

cellular

abnormal epigenetic regulation of gene expression ( J:198944 )

• compound heterozygous mice display a higher percentage of GFP-expressing cells than heterozygotes

• significantly reduced methylation of transgene DNA in homozygous individuals (28 % of CpGs methylated) compared with wild type littermates (62 % of CpGs methylated), consistent with the change in transcriptional activity

growth/size/body

abnormal head morphology ( J:198944 )

• hypotelorism and other cranial defects are seen, similar to phenotypes of other alleles of this gene

decreased body height ( J:198944 )

• small in stature