Del(17Trem1-Trem3)1Jkt
Targeted Allele Detail

Summary

• Symbol: Del(17Trem1-Trem3)1Jkt
• Name: deletion, Chr 17, Julia Klesney-Tait 1
• MGI ID: MGI:5486219
• Synonyms: Del1Jkt, TREM-1/3^-, TREM1&3^-, Trem1/Trem3^tm1.1Jkt
• Gene: Del(17Trem1-Trem3)1Jkt Location: unknown Genetic Position: Chr17, Syntenic

Del(17Trem1-Trem3)1Jkt/Del(17Trem1-Trem3)1Jkt mice show impaired pulmonary inflammation in response to P. aeruginosa challenge

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:194295
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intergenic deletion, Intragenic deletion Del(17Trem1-Trem3)1Jkt involves 2 genes/genome features (Trem1, Trem3) View all Mutation details: A floxed neo cassette replaced most of exon 3 and 4 of Trem1 and exon 1 of Trem3. Cre-mediated recombination removed the neo cassette. Flow cytometry confirmed the absence of protein expression in bone marrow granulocyte. (J:194295)

Generation of the Del(17Trem1-Trem3)1Jkt deletion

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(17Trem1-Trem3)1Jkt Mutation: 0 strains or lines available

References

• Original: J:194295 Klesney-Tait J, et al., Transepithelial migration of neutrophils into the lung requires TREM-1. J Clin Invest. 2013 Jan 2;123(1):138-49
• All: 7 reference(s)