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Del(17Trem1-Trem3)1Jkt Cytogenetic Marker Detail
Summary
  • Symbol
    Del(17Trem1-Trem3)1Jkt
  • Name
    deletion, Chr 17, Julia Klesney-Tait 1
  • Feature Type
    chromosomal deletion
  • IDs
    MGI:5584293
Location &
Maps
less
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 17, Syntenic
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    1 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele of Trem1 and Trem3 exhibit increased susceptibility to P. aeruginosa infection with reduced neutrophil transepithelial migration.
References
more
  • Summaries
    All 7
    Phenotypes 7
  • Earliest
    J:194295 Klesney-Tait J, et al., Transepithelial migration of neutrophils into the lung requires TREM-1. J Clin Invest. 2013 Jan 2;123(1):138-49
  • Latest
    J:344857 McQueen BE, et al., Reduced Uterine Tissue Damage during Chlamydia muridarum Infection in TREM-1,3-Deficient Mice. Infect Immun. 2021 Sep 16;89(10):e0007221
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory