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Trem3 Gene Detail
Summary
  • Symbol
    Trem3
  • Name
    triggering receptor expressed on myeloid cells 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930003
    NCBI Gene: 58218
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:48554805-48565869 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 23.99 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    40 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930003
 protein coding gene Chr17:48554707-48565876 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023865
 protein coding gene Chr17:49515927-49530307 (+)
A/J MGP_AJ_G0023825
 protein coding gene Chr17:48221628-48236490 (+)
AKR/J MGP_AKRJ_G0023793
 protein coding gene Chr17:48695381-48708144 (+)
BALB/cJ MGP_BALBcJ_G0023827
 protein coding gene Chr17:48148910-48160417 (+)
C3H/HeJ MGP_C3HHeJ_G0023590
 protein coding gene Chr17:49402470-49417143 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024270
 protein coding gene Chr17:51620352-51636328 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021719
 protein coding gene Chr17:44985766-44997333 (+)
CAST/EiJ MGP_CASTEiJ_G0023072
 protein coding gene Chr17:49585206-49599050 (+)
CBA/J MGP_CBAJ_G0023566
 protein coding gene Chr17:53464021-53479374 (+)
DBA/2J MGP_DBA2J_G0023695
 protein coding gene Chr17:46993053-47004275 (+)
FVB/NJ MGP_FVBNJ_G0023661
 protein coding gene Chr17:46653399-46664519 (+)
LP/J MGP_LPJ_G0023775
 protein coding gene Chr17:50224687-50237320 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023689
 protein coding gene Chr17:52961851-52978391 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024316
 protein coding gene Chr17:49035094-49046974 (+)
PWK/PhJ MGP_PWKPhJ_G0022817
 protein coding gene Chr17:46415799-46432792 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022631
 protein coding gene Chr17:45929850-45942655 (+)
WSB/EiJ MGP_WSBEiJ_G0023136
 protein coding gene Chr17:49620275-49635764 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotype references
Mice homozygous for a knock-out allele of Trem1 and Trem3 exhibit increased susceptibility to P. aeruginosa infection with reduced neutrophil transepithelial migration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    18
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    15
  • cDNA Data
    7
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041754 Ensembl Gene Model | MGI Sequence Detail 11065 C57BL/6J ±  kb
transcript ENSMUST00000048065 Ensembl | MGI Sequence Detail 994 Not Applicable  
polypeptide ENSMUSP00000044478 Ensembl | MGI Sequence Detail 183 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR013106 Immunoglobulin V-set domain
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 2
Other
Accession IDs
less
MGI:2147107
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:64954 Bouchon A, et al., Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J Immunol. 2000 May 15;164(10):4991-5
  • Latest
    J:344857 McQueen BE, et al., Reduced Uterine Tissue Damage during Chlamydia muridarum Infection in TREM-1,3-Deficient Mice. Infect Immun. 2021 Sep 16;89(10):e0007221
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory