Fzd1^tm1.1Boer
Targeted Allele Detail

Summary

• Symbol: Fzd1^tm1.1Boer
• Name: frizzled class receptor 1; targeted mutation 1.1, Derek Boerboom
• MGI ID: MGI:5465303
• Gene: Fzd1 Location: Chr5:4803839-4808035 bp, - strand Genetic Position: Chr5, 2.61 cM
• Alliance: Fzd1^tm1.1Boer page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:192479
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the coding sequence. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of the coding sequence. Cre-mediated recombination removed the coding sequence and left the FRT-flanked neo cassette intact. (J:192479)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fzd1 Mutation: 29 strains or lines available

References

• Original: J:192479 Lapointe E, et al., FZD1 regulates cumulus expansion genes and is required for normal female fertility in mice. Biol Reprod. 2012 Nov;87(5):104
• All: 1 reference(s)