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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fzd1tm1.1Boer
targeted mutation 1.1, Derek Boerboom
MGI:5465303
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fzd1tm1.1Boer/Fzd1tm1.1Boer involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J MGI:5465304


Genotype
MGI:5465304
hm1
Allelic
Composition
Fzd1tm1.1Boer/Fzd1tm1.1Boer
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fzd1tm1.1Boer mutation (0 available); any Fzd1 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• numerous invaginations of the ovarian surface epithelium formed tube-like structures in the ovarian cortex, and multiple nests of StAR- positive cells resembling lutein cells were present throughout the ovary of sterile female mice
• tubulostromal hyperplasia in sterile female mice
• however, fertile female mice exhibit normal ovaries
• in sterile mice
• however, fertile female mice exhibit normal follicle numbers
• very small in sterile female mice
• however, fertile female mice exhibit normal ovary weight
• stromal fibrosis in sterile female mice
• however, fertile female mice exhibit normal uteri
• some uterine glands in sterile female mice exhibit an ectopic layer of cells immediately beneath the columnar epithelial layer unlike in wild-type mice
• in sterile females
• some female mice fail to produce offspring
• female mice produce small litters compared with wild-type mice
• however, the number of litters is normal
• from some female mice

endocrine/exocrine glands
• some uterine glands in sterile female mice exhibit an ectopic layer of cells immediately beneath the columnar epithelial layer unlike in wild-type mice
• in sterile females
• numerous invaginations of the ovarian surface epithelium formed tube-like structures in the ovarian cortex, and multiple nests of StAR- positive cells resembling lutein cells were present throughout the ovary of sterile female mice
• tubulostromal hyperplasia in sterile female mice
• however, fertile female mice exhibit normal ovaries
• in sterile mice
• however, fertile female mice exhibit normal follicle numbers
• very small in sterile female mice
• however, fertile female mice exhibit normal ovary weight





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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory