Jhy^{Tg(Dlk1-lacZ)#aJvs}
Transgenic Allele Detail

Summary

• Symbol: Jhy^{Tg(Dlk1-lacZ)#aJvs}
• Name: junctional cadherin complex regulator; transgene insertion #a, Jennifer Schmidt
• MGI ID: MGI:5437647
• Synonyms: Jhy^lacZ
• Gene: Jhy Location: Chr9:40806145-40875414 bp, - strand Genetic Position: Chr9, 21.68 cM, cytoband B
• Alliance: Jhy^{Tg(Dlk1-lacZ)#aJvs} page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The transgene contains a genomic fragment of the mouse promoter from -248 bp to +50 bp of the transcriptional initiation site driving expression of a lacZ reporter gene preceeded by an SV40 splice donor-acceptor site and followed by a polyadenylation signal. 12 lines were generated. The unnamed line (#a) inserted into the beginning of exon 5 of the trapped gene and resulted in removal a splice acceptor site. Immunohistochemistry confirmed the absence of protein expression in the ependymal cells of the lateral ventricle. (J:202225)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jhy Mutation: 32 strains or lines available

References

• Original: J:202225 Appelbe OK, et al., Disruption of the mouse Jhy gene causes abnormal ciliary microtubule patterning and juvenile hydrocephalus. Dev Biol. 2013 Oct 1;382(1):172-85
• All: 2 reference(s)