Analysis Tools
mortality/aging
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• all hydrocephalic mice die or are sacrificed by 4 to 8 weeks of age
• however, mice with mild to no symptoms exhibit normal survival
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nervous system
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• sparser, shorter and of irregular length with random oriented and abnormal microtubule arrangement at P5 compared with wild-type mice
• however, transgenic expression of the endogenous gene from C57BL/6 partially rescues phenotype
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hydrocephaly
(
J:202225
)
|
• non-syndromic in more than half of mice between 2 and 5 weeks after birth
• however, transgenic expression of the endogenous gene from C57BL/6 partially rescues phenotype
|
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• at P5
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• in the brain at P5
• however, mice exhibit normal brain patterning
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skeleton
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• in more than half of mice
• however, transgenic expression of the endogenous gene from C57BL/6 partially rescues phenotype
|
behavior/neurological
growth/size/body
weight loss
(
J:202225
)
|
• early as heads enlarge and in non-hydrocephalic mice at 5 to 6 weeks
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craniofacial
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• in more than half of mice
• however, transgenic expression of the endogenous gene from C57BL/6 partially rescues phenotype
|
cellular
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• sparser, shorter and of irregular length with random oriented and abnormal microtubule arrangement at P5 compared with wild-type mice
• however, transgenic expression of the endogenous gene from C57BL/6 partially rescues phenotype
|
