Del(2Atf2)52Ddu
Targeted Allele Detail

Summary

• Symbol: Del(2Atf2)52Ddu
• Name: deletion, Chr 2, Denis Duboule 52
• MGI ID: MGI:5305752
• Synonyms: Del(rel5-Atf2)
• Gene: Del(2Atf2)52Ddu Location: unknown Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178930
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Del(2Atf2)52Ddu involves 2 genes/genome features (Atf2, Atp5mc3) View all
• Mutation details: A 590 kb deletion was induced by cre mediated recombination between Is(2)46Ddu and Atf2^tm3Nicj . The deletion encompasses the entire gene desert upstream of Lnp and part of Atf2. At E12.5 mRNA expression levels of Lnp, Evx2, Hoxd13, Hoxd12, Hoxd11, and Hoxd10 are reduced to about 20% of wild-type levels in the developing digits. (J:178930, J:192248)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(2Atf2)52Ddu Mutation: 0 strains or lines available

References

• Original: J:178930 Montavon T, et al., A regulatory archipelago controls hox genes transcription in digits. Cell. 2011 Nov 23;147(5):1132-45
• All: 2 reference(s)