Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Atf2tm3Nicj
Name:	activating transcription factor 2; targeted mutation 3, Nic Jones
MGI ID:	MGI:3774771
Synonyms:	ATF2f
Gene:	Atf2  Location: Chr2:73646853-73722983 bp, - strand  Genetic Position: Chr2, 43.86 cM
Alliance:	Atf2tm3Nicj page

Germline Transmission:	Earliest citation of germline transmission: J:123909
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Exons 8 and 9 encoding the DNA-binding domain and a portion of the leucine zipper were flanked by loxP sites. Gene expression was comparable to wild-type in numerous tissues. (J:131564)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

List all tumor models in MMHCdb carrying Atf2tm3Nicj

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atf2 Mutation:	89 strains or lines available

Original:	J:123909 Breitwieser W, et al., Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells. Genes Dev. 2007 Aug 15;21(16):2069-82
All:	10 reference(s)