Analysis Tools
normal phenotype
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• mice were born at the expected Mendelian frequencies and presented no obvious abnormalities
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Allele Symbol Allele Name Allele ID |
Atf2tm3Nicj targeted mutation 3, Nic Jones MGI:3774771 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice were born at the expected Mendelian frequencies and presented no obvious abnormalities
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the median appearance of skin papillomas after topical application of carcinogens is five to six weeks earlier than in littermate controls
• mice have significantly greater numbers of papillomas 20 weeks after carcinogen treatment with a mean of 7 compared to 3 in littermate controls
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• the percentage of proliferating epithelial cells after TPA administration is twice that of littermate controls
• reduced levels of active caspase 3 were observed in the skin of mice treated with carcinogens suggesting apoptosis levels might be lower
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• mice develop a significantly thickened hyperdermis after three topical applications of TPA
• thickness is twice that of wild-type mice after TPA application
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• the median appearance of skin papillomas after topical application of carcinogens is five to six weeks earlier than in littermate controls
• mice have significantly greater numbers of papillomas 20 weeks after carcinogen treatment with a mean of 7 compared to 3 in littermate controls
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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