Tg(CEPHY230E8)50Hgc
Transgene Detail

Summary

• Symbol: Tg(CEPHY230E8)50Hgc
• Name: transgene insertion 50, Edward M Rubin
• MGI ID: MGI:5291633
• Synonyms: 230E8, Tg(YAC230E8)50Hgc, YAC 230E8, YAC 230E8 Line 50, YAC Lg 50
• Transgene: Tg(CEPHY230E8)50Hgc Location: unknown
• Alliance: Tg(CEPHY230E8)50Hgc page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CEPHY230E8)50Hgc expresses 5 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CBR1 (873)

  Cbr1	(MGI:88284)
  Cbr1b	(MGI:3646098)

  human

  CBR3 (874)

  Cbr3	(MGI:1309992)

  human

  CHAF1B (8208)

  Chaf1b

  (MGI:1314881)

  human

  DOP1B (9980)

  Dop1b

  (MGI:1917278)

  human

  MORC3 (23515)

  Morc3

  (MGI:2136841)

• Mutation details: The transgene comprises a yeast artificial chromosome (YAC) from the CEPH Whole Genome MegaYAC Library carrying a 670-kb fragment of DNA from human Chromosome 21 containing the genes CBR1 (carbonyl reductase 1), CBR3 (carbonyl reductase 3), DOPEY2 (dopey family member 2; formerly C21orf5), MORC3 (MORC family CW-type zinc finger 3; formerly KIAA0136), and CHAF1B (chromatin assembly factor 1, subunit B (p60)). This transgenic line was shown by Southern blot analysis to bear a single copy of the YAC. (J:128897)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:128897 Smith DJ, et al., Construction of a panel of transgenic mice containing a contiguous 2-Mb set of YAC/P1 clones from human chromosome 21q22.2. Genomics. 1995 Jun 10;27(3):425-34
• All: 5 reference(s)