S1pr2^tm1Ytak
Targeted Allele Detail

Summary

• Symbol: S1pr2^tm1Ytak
• Name: sphingosine-1-phosphate receptor 2; targeted mutation 1, Yoh Takuwa
• MGI ID: MGI:4881823
• Gene: S1pr2 Location: Chr9:20877248-20888089 bp, - strand Genetic Position: Chr9, 7.68 cM
• Alliance: S1pr2^tm1Ytak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:168060
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding exon was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on uterus, testis, kidney, spleen, liver, lung, heart, and brain extracts. (J:168060)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any S1pr2 Mutation: 46 strains or lines available

References

• Original: J:168060 Du W, et al., S1P(2), the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice. Cancer Res. 2010 Jan 15;70(2):772-81
• All: 4 reference(s)