Phenotypes associated with this allele

• Allele Symbol: S1pr2^tm1Ytak
• Allele Name: targeted mutation 1, Yoh Takuwa
• Allele ID: MGI:4881823
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	S1pr2^tm1Ytak/S1pr2^tm1Ytak	involves: 129P2/OlaHsd * C57BL/6	MGI:4881834

Genotype
MGI:4881834

hm1

• Allelic Composition: S1pr2^tm1Ytak/S1pr2^tm1Ytak
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

respiratory system

increased lung endothelial cell migration ( J:168060 )

• mouse lung endothelial cells exhibit increased migration and tube formation in a wound healing assay in the presence of VEGF compared with wild-type cells

mortality/aging

postnatal lethality, incomplete penetrance ( J:168060 )

• around weaning, some mice exhibit seizures that result in death

neoplasm

abnormal tumor vascularization ( J:168060 )

• tumors from mice transplanted with LLC and B16BL6 melanoma cells exhibit increased microvessel density with increased pericytes compared with tumors from similarly treated wild-type mice

abnormal tumor morphology ( J:168060 )

• mice transplanted with LLC and B16BL6 melanoma cells exhibit increased tumor infiltration of myeloid cells compared with similarly treated wild-type mice

increased tumor growth/size ( J:168060 )

• mice transplanted with LLC and B16BL6 melanoma cells exhibit increased tumor volume and tumor weight compared with similarly treated wild-type mice

cardiovascular system

abnormal tumor vascularization ( J:168060 )

• tumors from mice transplanted with LLC and B16BL6 melanoma cells exhibit increased microvessel density with increased pericytes compared with tumors from similarly treated wild-type mice

increased angiogenesis ( J:168060 )

• in a matrigel plug assay

cellular

increased lung endothelial cell migration ( J:168060 )

• mouse lung endothelial cells exhibit increased migration and tube formation in a wound healing assay in the presence of VEGF compared with wild-type cells

nervous system

seizures ( J:168060 )

• around weaning, some mice exhibit seizures that result in death

behavior/neurological

seizures ( J:168060 )

• around weaning, some mice exhibit seizures that result in death