Zfp36l2^tm2Pjb
Targeted Allele Detail

Summary

• Symbol: Zfp36l2^tm2Pjb
• Name: zinc finger protein 36, C3H type-like 2; targeted mutation 2, Perry J Blackshear
• MGI ID: MGI:4360890
• Gene: Zfp36l2 Location: Chr17:84491359-84495375 bp, - strand Genetic Position: Chr17, 55.02 cM, cytoband E4
• Alliance: Zfp36l2^tm2Pjb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:152911
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting vector was designed to replace most of the protein-coding region (bases 257-1242), including the tandem zinc finger domain, with a PGKNeo cassette. Northern analysis demonstrated that no detectable mRNA was seen in the livers from homozygous mice. (J:152911)

Expression

In Mice Carrying this Mutation:	12 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zfp36l2 Mutation: 20 strains or lines available

References

• Original: J:152911 Stumpo DJ, et al., Targeted disruption of Zfp36l2, encoding a CCCH tandem zinc finger RNA-binding protein, results in defective hematopoiesis. Blood. 2009 Sep 17;114(12):2401-10
• All: 2 reference(s)