All Phenotypes Zfp36l2<tm2Pjb> MGI Mouse

mortality/aging

postnatal lethality, complete penetrance ( J:152911 )

• most die within 2 weeks of birth

growth/size/body

decreased body size ( J:152911 )

• about half are smaller than controls

• half the size of controls

hematopoietic system

abnormal embryonic hematopoiesis ( J:152911 )

• decreased myeloid (CFU-GM, 18-fold) progenitors in yolk sacs

• decreased multipotential (CFU-GEMM, 10-fold) progenitors in yolk sacs

• normal primitive hematopoiesis

abnormal definitive hematopoiesis ( J:152911 )

• decreased erythroid (BFU-E, 10-fold)

• decreased granulocyte macrophage (CFU-GM, 32-fold)

• decreased granulocyte macrophage/macrophage (CFUGM/M, 14-fold)

• decreased multipotential (CFU-GEMM, 14-fold) progenitor cells

extramedullary hematopoiesis ( J:152911 )

• multinodular erythropoiesis in the spleen

anemia ( J:152911 )

• apparent variability in the onset of severe anemia (8 to 51 days of age)

decreased bone marrow cell number ( J:152911 )

• hypocellular bone marrow

• a 2-fold decrease in the percentage of myeloid cells

• decreased Lin-/Sca-1-/c-Kit+ (LSK) bone marrow cells (include hematopoietic stem cells)

decreased erythrocyte cell number ( J:152911 )

• 2.3 fold reduction in number

decreased hematocrit ( J:152911 )

• 1.6 fold reduction

decreased hemoglobin content ( J:152911 )

• 1.6 fold reduction

increased nucleated erythrocyte cell number ( J:152911 )

thrombocytopenia ( J:152911 )

• 11 fold decrease in platelet count

decreased leukocyte cell number ( J:152911 )

• 2.1 fold reduction in number

decreased neutrophil cell number ( J:152911 )

• 5.4 fold reduction in neutrophils

pancytopenia ( J:152911 )

decreased splenocyte number ( J:152911 )

• myeloid and megakaryocyte cell populations are decreased 4-fold and 14-fold

abnormal bone marrow cell physiology ( J:152911 )

• both the short- and longer-term reconstituting capacities of fetal liver cells are greatly compromised

liver/biliary system

abnormal liver morphology ( J:152911 )

• decreased nucleated cellularity in the fetal liver

pale liver ( J:152911 )

renal/urinary system

pale kidney ( J:152911 )

cardiovascular system

hemorrhage ( J:152911 )

• pallor of the skin, liver, and kidneys in necropsied mice, often accompanied by overt hemorrhage

intestinal hemorrhage ( J:152911 )

• frequent intestinal hemorrhage

subcutaneous hemorrhage ( J:152911 )

• subcutaneous hemorrhages often visible in living mice

immune system